Almost 450,000 people died from an overdose involving any opioid between 1999–2018, including prescription and illicit opioids. The U.S. opioid overdose epidemic is a major public health crisis, and health systems across the country are trying to develop new approaches, technologies and tools to combat this situation. Apart from the significant toll on patients and their loved ones, hospitals also struggle with readmission rates and excess length of stay associated with opioid-related substance abuse hospitalizations.